Structural analyses on small sets of proteins have shown that the domains from a pair of families bind to each other with the same geometry in multi-domain proteins and in transient interactions.

The yeast two-hybrid method allows the mapping of binary or pair-wise interactions, protein chips are suited to detect protein–protein, pro- tein–lipid and other protein–ligand interactions.

Topics include: Protein – Protein Interactions, Structural Analyses of Domain Interactions, & The Use of Gene Order & Phylogeny to Predict Protein – Protein Interactions.