A rare, progressive encephalopathy associated with aberrant prion protein particles. May be transmitted via organ transplantation (including corneal transplant). 'Mad cow' is the prion disease in cattle that when transmitted to humans causes a variant form of Creutzfeldt-Jakob disease.

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1. A rare, progressive encephalopathy associated with aberrant prion protein particles. May be transmitted via organ transplantation (including corneal transplant). 'Mad cow' is the prion disease in cattle that when transmitted to humans causes a variant form of Creutzfeldt-Jakob disease.