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Bioinformatics Practice Test Questions: Functional Genomics & Proteomics
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Avg score: 64% • Most missed: “Which of the following is untrue regarding the classic yeast two-hybrid method?”
Functional genomics: Studies the function and expression of the genome, including how genes and intergenic segments contribute to metabolic pathways. It also studies how different segments of an organism work together to produce a phenotype. Proteomics: Studies the interactions, function, composition, and structures of proteins and their cellular activities. It focuses on identifying when and where proteins are expressed in a cell to establish their physiological roles. Proteomics provides a better understanding of the structure and function of the organism than genomics.   Topics... Show more
Bioinformatics Practice Test Questions: Functional Genomics & Proteomics
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25 Questions

1. For many eukaryotic proteins, newly synthesized protein precursors have to be transported to specific membrane-bound compartments and be proteolytically processed to become functional.
2. To generate EST data, clones in the cDNA library are randomly selected for sequencing from either end of the inserts.
3. ExPASY is a comprehensive proteomics web server with a suite of programs for searching peptide information from the SWISS-PROT and TrEMBL databases.
4. Which of the following is an incorrect statement about the terminologies related to protein sorting?
5. It is important to use bioinformatics tools to predict sites for posttranslational modifications based on specific protein sequences. However, prediction of such modifications can often be difficult because the short lengths of the sequence motifs associated with certain modifications.
6. If the bait and prey proteins _______ they bring the DNA-binding and trans-activation domains in such close proximity that they reconstitute the function of the transcription activator, turning ____ the expression of a reporter gene as a result. Which of the following is not the correct pair of blanks?
7. The signal sequences have a _________ consensus but contain some specific features. They all have a ______ core region preceded by one or more positively charged residues.
8. Which of the following is untrue about SAGE Genie?
9. It has been estimated that up to 11% of cDNA clones may be chimeric.
10. Which of the following is incorrect regarding Mass Spectrometry Protein Identification?
11. Which of the following is untrue about SAGE?
12. The signal sequences are typically _______ residues long, rich in _____ charged residues such as arginines as well as hydroxyl residues such as serines and threonines, but devoid of ______ charged residues.
13. Comparing two-dimensional gel images from various experiments can sometimes pose a challenge because the gels, unlike DNA microarrays, may shrink or warp.
14. Which of the following is an incorrect statement?
15. The justification behind Rosetta stone method is that when two domains are fused in a single protein, they have to be in _______ proximity to perform a common function.
16. Which of the following is untrue regarding the classic yeast two-hybrid method?
17. Which of the following is untrue regarding the Predicting Interactions Based on Domain Fusion?
18. Once the proteins are translocated within the organelles, protease cleavage takes place to remove the signal sequences and generate mature proteins.
19. Accurate prediction of _____ bonds may also help to predict the _____ dimensional structure of the protein of interest.
20. Which of the following is an incorrect statement about SignalP?
21. Chloroplast localization signals are also located in the __________ terminus and are about 25 to 100 residues in length, containing very few _______ charged residues but many hydroxylated residues such as serine.
22. Which of the following is untrue regarding EST Index Construction?
23. Which of the following is incorrect regarding 2D-Page?
24. Which of the following is untrue regarding UniGene?
25. Which of the following is not one of the training sets in SignalP?

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