GRAIL is a web-based program that is based on a neural network algorithm Which is trained on several statistical features such as splice junctions, start and stop codons, poly-A sites, promoters, and CpG islands.

Gene and promoter prediction is a crucial research area in bioinformatics. Accurate prediction of promoters is important for understanding gene function and regulation, and for interpreting gene expression patterns.

Topics include: Categories of Gene Prediction Programs, Gene Prediction in Prokaryotes, & Gene Prediction in Eukaryotes.