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Bioinformatics Practice Test Questions: Structural Bioinformatics
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Avg score: 75% Most missed: “Which of the following is untrue about SCOP?”

Structural bioinformatics is a multidisciplinary field that analyzes and predicts the three-dimensional structures of biological macromolecules. This includes proteins, RNA, and DNA.

Topics include: Protein Structure Basics, Protein Structural Visualization, Protein Structure Comparison, & Protein Structure Classification.

Bioinformatics Practice Test Questions: Structural Bioinformatics
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25 Questions

1. Which of the following is an incorrect statement?
2. Which of the following is not correct about the X-ray Crystallography?
3. Which of the following is incorrect about Multiple Structure Alignment?
4. One can search a structure in PDB using the four-letter code or keywords related to its annotation.
5. The second step in structure classification is to separate structurally distinct domains within a structure.
6. ______ the smallest amino acid, has a hydrogen atom as the R group.
7. Ribbon diagrams use cylinders or spiral ribbons to represent α-helices and broad, flat arrows to represent β-strands.
8. Balls and sticks are solid spheres and rods, representing atoms and bonds, respectively.
9. Which of the following is not correct about the β-sheet?
10. Which of the following is not correct about the α-Helices?
11. The intramolecular approach does not depend on sequence similarity between the proteins to be compared.
12. In CATH, Structural domain separation is carried by ___________
13. A linear polymer of more than fifty amino acid residues is referred to as a ________
14. CATH is a combination of manual curation and automated procedure, which makes the process less subjective.
15. Which of the following is not correct about the stabilizing Forces?
16. The last step in structure classification involves grouping proteins/domains of similar structures.
17. The root mean square deviation (RMSD), with the size dependency correction is?
18. Which of the following is not correct?
19. Which of the following is untrue about SCOP?
20. Which of the following is wrong about Swiss-PDB Viewer?
21. Which of the following is an incorrect statement?
22. A Protein Data Bank (PDB) data file for a protein structure contains only x, and z coordinates of atoms.
23. The building blocks of proteins are ______ naturally occurring amino acids, small molecules that contain a free amino group (NH2) and a free carboxyl group (COOH).
24. Which of the following is incorrect about protein structure comparison?
25. Globular proteins are usually insoluble.

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