The R group or side chain of the amino acid serine is –CH2–OH. The R group or side chain of the amino acid leucine is –CH2–CH–(CH3)2. Where would you expect to find these amino acids in a globular protein in aqueous solution?

Large biological molecules, also known as macromolecules, are essential for life. They are produced by living organisms and are essential for biological processes such as cell division, development, and morphogenesis. 

The four major types of large biological molecules are:
Carbohydrates: Such as sugars
Lipids: Such as fats
Proteins: Large, complex molecules that play many critical roles in the body
Nucleic acids: Such as DNA and RNA