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USMLE Musculoskeletal System Question Bank

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Your musculoskeletal system includes your bones, cartilage, ligaments, tendons and connective tissues. Your skeleton provides a framework for your muscles and other soft tissues. Together, they support your body's weight, maintain your posture and help you move.

USMLE Musculoskeletal System Question Bank

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25 Questions

1. What is Osteogenesis imperfecta? 2. Characteristics of this pathology? 3. Specific distinct occular findings in this disease? 4. Specific auditory findings?

1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.1. C6 2. Transverse foramina 3. Foramen magnum1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.

2. A person with recent onset pain, tingling in left arm has: -Absent sensation to light touch/pinprick on fourth and fifth digits of left hand and medial forarme. -Clawing of all digits. -Rotating head to left causes loss of radial pulse. X ray shows cervical rib. 1. What condition does this person likely have. 2. What structure is likely being compressed? 3. What is the test called that was performed?

1. C6 2. Transverse foramina 3. Foramen magnum1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.

3. Non proliferative synovitis with neutrophils and abscess formation is seen in what condition? 2. What are the common aetiologies for this?

1. C6 2. Transverse foramina 3. Foramen magnum1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)

4. At what cervical level do the vertibral arteries enter the spinal column? 2. What are these passagways through the cervical spine called that they travel through? 3. Where do they enter the skull at?

1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.1. C6 2. Transverse foramina 3. Foramen magnum1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)

5. Organism that causes lyme disease? What is it? 2. What rash is caused by this? 3. What are symptoms after dessemination? 4. Long term sequale? 5. Treatment?

1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.'1. Borrelia burgdorferi; spirochete transmitted by Ixodes scapularis deer tick. 2. Erythema migrans = enlarging ''target-shaped'' rash. 3. Neurological symptoms: Cranial nerve palsies, Cardiac symptoms. 4. Arthritis: Months to years late. Thought to be type 3 HS. 5. Doxycyclcine'1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)

6. What is the collagen type that is degraded in osteoarthritis?

1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)Type 2 collagen It is enzymatic degradation of articular hyaline cartilage1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.

7. What mutation is the cause of myotonic dystrophy?

1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.1. Protein kinase

8. A person is stabbed on posterolateral neck and has suffered partially severing of C6 ventral ramus. What finding is likely to be found related to this injury

1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.C5-C7 nerve roots = long thoracic nerve which = serratus anterior. So they get inability to protract scapula = winged scapula.1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)

9. An increase in calcium and alkaline phosphatase and a decrease in phosphate is associated with what condition?

1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.Primary hyperparathyroidism.

10. What is triad for reactive arthritis? 2. What is reactive arthritis? 3. What HLA haplotype is implicated?

1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.1. Arthritis, urethritis, conjuctivitis. 2. Autoimmune reaction to prior infection to: -C. jejuni -Salmonella -SHigella -Yersinia -Chlamydia 3. HLA-B27

11. Alpha fetoprotien is associated with what malignacies?

1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.-Yolk sac tumors -Hepatocellular carcinoma1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.

12. What nerve is commonly compressed in pregnant women? 2. What muscles are innervated by this nerve? 3. What is the cutaneous innervation of this nerve.

1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)1. Mediam nerve = carpal tunnel syndrome. 2. Abductor pollicis brevis Flexor pollicis brevis Opponens pollicis 3. Ventral lateral aspects of palm from the lateral half or the fourth digit to the thumb and ventral and dorsal fingertips of the first three lateral digits and the lateral half of the fourth fingertip.1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.

13. What is osteopetrosis? 2. What is cause of the disease? 3. What are clinical features of the disease?

1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)1. Stone bone disease. Bones become denser. 2. Ineffective osteoclasts that fail to properly reabsorb bone. 3. X-ray of long bones show broad metaphysis and diaphysis. Narrowing cranial foramina cause nerve compression = hearing loss, facial nerve palsy and hydrocephalus Dacrocytes1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.

14. A women diagnosed with rheumatoid arthritis begins treatment but after several months blood work shows that she is: -Anemic -Leukopenic -Thrombocytopenic -Slight increase in mean corpuscular volume 1. Addition of what to her treatment would most likely have prevented these symptoms? 2. What drug treatment is she being given? 3. What are adversce side effects of this drug?

1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)1. Folic acid 2. Methotrexate 3. Stomatitis, GIT, pancytopenia1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.

15. What anti-inflammatory is most appropriate in an individual with hx of ulcers that is presenting for treatment with rheumatoid arthritis and why?

Celecoxib: -Selective for COX-1 = anti inflammatory, analgesic, antipyretic. -Spares COX-1 = spares prostaglanding production which is important for GI linning.1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)

16. Acute monoarticular arthritis is suggestive of what sort of cause?

1. Infectious cause.1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.

17. Where does the radial nerve lie on the humerus?

1. Musculospiral groove1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.

18. A lady skying grabs a tree branch over head to avoid hitting another skier. She now has: -Weakness/numbness of right upper extremity - Pain and numbness in ulnar two fingers and ulnar aspect of palm -Clawing of index, middle, ring and small fingers of right hand. What did you most likely injure?

1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.Lower trunk of brachial plexus Lower trunk of brachial plexus = nerve fibers from C8-T1 = loss of intrinsic hand muscles and numbness of inner aspect s. This is Klumpke palsy.1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)

19. What are some associated symptoms of Pagets disease?

1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)-Frontal bossing = increased hat/show size -Hearing loss = auditory foramen narrowing. -High out put cardiac fialure from arterio venous shunts in moasic bone -Osteosarcoma1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.

20. A fracture to the lateral epicondyle of the humerus would injure what nerve? 2. How would this present clinically?

1. Radial nerve 2. Wrist drop. Inability to used extensors1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.

21. What purpose does protein kinase C have in muscle contraction? 2. Function of troponin?

1. Initiates contraction of smooth muscle. 2. Hides binding site for myosin on actin thin filament until Ca binds = conformation change = reveals site.1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.

22. Marathon runners leg will have higher concentration of what? 2. A sprinters leg will have a higher concentration of what?

1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)1. Red fibers (type 1)= -Endurance -Myoglobin -Mitochondrial -Aerobic metablosim capacity 2. White fibers (type2) -Fast response -Glycogen -Diameter1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.

23. How does botox work? 2. What organism is it derived from?

1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.1. Prevents Ach release at the neuromuscular junction = paralysis. 2. Clostridium botulinum; gram postive, spore forming, obligate anaerobe.1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)

24. What does ethylene glycol poisoning do to the body?

1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.1. -Causes metabolic acidosis from increase glycolate. -Causes deposition of oxalate crystals in tissues. -Can cause AKI.1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.

25. What is osteochondritis dissecans?

1. Thoracic outlet syndrome. 2. Lower trunk of the brachial plexus. Thoracic outlet syndrome causes compression of neurovascular bundles of the lower trunk of the brachial plexus 3. Adson test Rotating head to ipsilateral side with neck extension causes compression of subclavian = loss radial pulse.1. Hereditary disorder causing abnormal synthesis of type 1 collagen. Alpha chain abnormalities. 2. Generalized osteopenia, recurrent fractures, skeletal deformities. 3. Thin sclera with blue hue. 4. Deafness due to involvement of bones in middle ear.'''Joint mice'' that have broken off in the joint.'1. Septic arthritis. 2. Haemophilus influenzae Staphylococcus Streptococcus Gonococcus Gram negatives (E. coli, salmonella pseudomonas.)

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25 Questions

❤ If you liked Fatskills, consider supporting us by checking out The Life Manuals You Never Got.

About | Explore | User Guide | Topics | Subjects | Doubt Solver | Career Aptitude Test | Answers | Free Tools | What Should We Know? Privacy | Terms |

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All trademarks, logos and brand names are the property of their respective owners. All company, product and service names used in this website are for identification purposes only. Use of these names, trademarks and brands does not imply endorsement.

About | Explore | User Guide | Topics | Subjects | Doubt Solver | Career Aptitude Test | Answers | Free Tools | What Should We Know?
Privacy | Terms |

Without work one finishes nothing. - Ralph Waldo Emerson
© 2026 Fatskills.com