GPAT Paper 2012
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GPAT Paper 2012
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25 Questions

1. Misoprostol has a cytoprotective action on gastrointestinal mucosa because of one of the following actions. Identify that.
2. Which one of the following receptors is not a ligandgated ion channel receptor?
3. Major component of Cymbopogon citratus is citral which is utilized commercially for the synthesis od vitamin A from the following: [P]: Directly from citral [Q]: By first converting to T-ionone [R]: By first converting to T-ionone followed by conversion to a-ionone which is very important intermediate for carotenoid synthesis [S]: By first conversion of citral to T-ionone followed by conversion to P-ionone which is an important intermediate for carotenoid synthesis Which is the correct combination of options?
4. Corticosteroids are administered to treat some of the given disease states: [P]: Peptic ulcer [Q]: Bronchial asthma [R]: Nephrotic syndrome [S]: Myasthenia gravis Choose the correct statement about the use of corticosteroids for the treatment of these diseases.
5. Choose the correct combination: (i) Rod mill (ii) Hammer mill (iii) Fluid energy mill (p) Dried plant drug (q) Thermolabile drug (r) Paint
6. Study the following four statements: [P]: Gram negative bacteria produce potent pyrogenic substances called endotoxins [Q]: Ethylene oxide mixed with carbon dioxide or fluorinated hydrocarbons is used in gas sterilization [R]: D value is the time (for heat or chemical exposure) or the dose (for radiation exposure) required for the microbial population to decline by one logarithmic unit [S]: Spores of Geobacillus stearothermophilus (Bacillus stearothermophilus) are used for sterility testing of moist heat sterilization process Choose the correct answer.
7. Containers used for aerosols should withstand a pressure of:
8. Which one of the following amino acids is the most effective contributor of protein buffer?
9. Naringin, obtained from orange peel, can be named as one of the following. Identify the correct name.
10. At equal concentrations which one of the following mucilages will possess maximum viscosity?
11. Some statements are given about disodium edetate: [P]: Disodium edetate is a bidentate ligand [Q]: Disodium edetate is a complexing agent but not a chelating agent [R]: Disodium edetate can be used for the assay of lithium carbonate [S]: Disodium edetate can be used for the assay of zinc sulphate Choose the correct answer.
12. Identify the group of enzymes that utilizes NADP or NAD as coenzymes and catalyses biochemical reactions by the transfer of electrons from one molecule to another.
13. For the equation PV = nRT to hold true for a gas, all of the following conditions are necessary except for one. Identify that.
14. Which one of the following statements is not true for stainless steel 316?
15. Read the following statements carefully about nonaqueous titrations: [P]: Acetate ion is the strongest base capable of existence in acetic acid. [Q]: Mixtures of bases of different strengths can be analyzed by selecting a differentiating solvent for the bases. [R]: Acetic acid acts as a leveling solvent for various acids like perchloric and hydrochloric acids. [S]: Mixtures of bases of different strengths can be analyzed by selecting a leveling solvent for the bases. Choose the correct answer.
16. Precessional frequency of a nucleus depends on the following: [P]: Quantum of externally applied magnetic field [Q]: Quantum of electron density present around the nucleus [R]: Frequency of applied electromagnetic radiations [S]: Electronegativity of the element Choose the correct combination of statements.
17. If M, L, T, Q and θ are dimensional representations of mass, length, time, heat and temperature respectively, then what is the dimension of fluid thermal conductivity?
18. Cetirizine as an antihistaminic agent has a low sedative potential due to one of the following reasons. Identify that.
19. Given are some statements about cycloalkanes: [P]: Bayer's theory does not apply to four membered rings. [Q]: Cyclohexane and cyclodecane rings are not flat but are puckered. [R]: Chair form of cyclohexane experiences van der Waals strain due to flagpole interactions. [S]: Boat form of cyclohexane experiences both torsional and van der Waals strain. Choose the correct combination of statements.
20. Which one of the following colours is not permitted to be used in drugs by the Drugs and Cosmetics Act, 1940?
21. Given are the four statements about dehydration of alcohols to give alkenes: [P]: Ease of dehydration of alcohols takes place in the order 3°> 2°>1° [Q]: Dehydration is acid catalyzed. [R]: Orientation of the alkene formed is strongly Saytzeff. [S]: Dehydration is irreversible. Choose the correct combination of statements.
22. There are some statements related to the protein binding of drugs as given below: [P]: Protein binding decreases the free drug concentration in the system. [Q]: Protein binding to plasma albumin is an irreversible process. [R]: Drugs with a low lipophilicity have a high degree of protein binding. [S]: Protein binding of one drug can be affected by the presence of other drug. Choose the correct combination of statements.
23. Which one of the following fragmentation pathways involves a double bond and a y- hydrogen in mass spectrometry?
24. Study the following two statements: [X]: If the gas is cooled below its critical temperature, less pressure is required to liquefy it. [Y]: At critical temperature and critical pressure, the liquid will have highest vapor pressure. Choose the correct combination of statements.
25. Following are some opioid analgesics: [P]: Morphine [Q]: Pethidine [R]: Pentazocine [S]: Fentanyl Choose the correct order of respiratory depressant propensity of these agents.