Which of the following is/are the application of analytical centrifugation?I. The determination of the purity of macromolecules.II. The determination of the relative molecular masses of solutes in their native state.III. The examination of changes in the molecular mass of supramolecular complexes.IV. The detection of conformational changes.

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Which of the following is/are the application of analytical centrifugation?<br />I. The determination of the purity of macromolecules.<br />II. The determination of the relative molecular masses of solutes in their native state.<br />III. The examination of changes in the molecular mass of supramolecular complexes.<br />IV. The detection of conformational changes.