1. Gram negative organisms are largely insensitive to benzyl penicillin because

2. Roxithromycin has the following advantages over erythromycin except

3. Which one of the following drugs is most likely to be effective against multidrug – resistant strains of M tuberculosis, including those resistant to streptomycin?

4. The most important reason for highly restricted use of penicillin G injections in present day therapeutics is its

5. Cyclosporine

6. Sulfamethoxypyridazine and other related long acting sulfonamides have now gone into disuse because

7. The most frequent side effect of oral ampicillin is

8. The most important mechanism of bacterial resistance to an aminoglycoside antibiotic is

9. Erythromycin is the drug of choice in

10. The persistent suppression of bacterial growth that may occur following limited exposure to some antimicrobial drugs is called

11. In renal failure safest tetracycline is

12. Chloramphenicol is the drug of choice in

13. Methicillin resistant staphylococci do not respond to β-lactam antibiotics because

14. Bleomycin is used in most effective drug combination regiment for the chemotherapy of testicular carcinoma. Which one of the following statements about the drug is accurate?

15. Which of the following is a steroidal antibiotic

16. Drug of choice for ringworm infection is

17. The tetracycline safe in renal failure is

18. Streptomycin sulfate is not absorbed orally because it is

19. Streptomycin is more active at

20. Which toxic effect of aminoglycoside antibiotics is most irreversible in nature ?

21. Superinfections are more common with

22. Select the antibiotic whose dose must be reduced in patients with renal insufficiency

23. Which antimicrobial should be avoided in patients of liver disease ?

24. A 36-year-old woman recently treated for leukemia is admitted to hospital with malaise, chills and high fever. Gram stain of blood reveals the presence of gramnegative bacilli. The initial diagnosis is bacteremia and parenteral antibiotics are indicated. The records of the patient reveal that she had a severe uriticarial risk, hypotension, and respiratory difficulty following oral penicillin V about 6 months ago. The most appropriate drug regimen for empiric treatment is

25. In a patient with culture-positive enterococcal endocarditis who has failed to respond to vancomycin because of resistance, the treatment most likely to be effective is