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USMLE Step 1 Immunology
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USMLE Step 1 Immunology
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25 Questions

1. What is the pathogenesis of a hypersensitivity reaction?

2. other than mediating shock - what else does TNF alpha do? who releases it mainly?

3. What is colostrum?

4. Which is the main antibody that provides passive immunity to infants?

5. what cytokine does basophils secrete?

6. what cell surface marker is used for NK cells as it is unique to them?

7. which antibody is involved in the primary response or immediate response to an antigen?

8. What is chronic mucocutaneous candidiasis d/t?

9. What is the pathogenesis of HyperIgE syndrome? What are the labs?

10. What is the late phase reaction of anaphylaxis allergy? what mediates it?

11. What are the function of B cells?

12. which antibody activate mast cells - basophils - and eosinophils?

13. What lymph node drains the scrotum?

14. What is the general structure of an Ab?

15. What is the main function of IL 12? other than macrophages who else can release IL 12?

16. describe the pathogenesis of delayed type IV hypersensitivity

17. What is the pathogenesis of chronic transplant rejection? When does it occur? is it reversible?

18. What happens when a T helper cell in the paracortical section encounters an antigen? a cytotoxic t cell? a B cell in the cortical section?

19. What are complements in the complement system? What activates them? there seems to be different ones - What are these pathways called?

20. What is the presentation of scid? treatment?

21. What are the cell surface proteins for Macrophages? which two are for opsonins?

22. What does interferon gamma do? What two type of cells does it attack mostly?

23. What is the two fates of the RBCs that go through the spleen? what happens eventually to all of them>

24. What type of fenestrations are found in the red pulp of the spleen?

25. give an example of a virus that uses antigenic variation. What does a major variation result in? minor?

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