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____: For an autosomal dominant condition where the reproductive fitness (f) is zero (i.e. affected persons do not survive to reproduce and/or are infertile) then all cases represent new mutations. Since each child inherits 2 genes (each could mutate) then the incidence (I) of disease is really twice the mutation rate → I = 2μ

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1. ____: For an autosomal dominant condition where the reproductive fitness (f) is zero (i.e. affected persons do not survive to reproduce and/or are infertile) then all cases represent new mutations. Since each child inherits 2 genes (each could mutate) then the incidence (I) of disease is really twice the mutation rate → I = 2μ





 
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