Historically, this common X-linked disease was a problem, since carrier detection was unsatisfactory and prenatal diagnosis impossible. In the 1980s several closely linked DNA probes spanning the gene locus became available; thus increasing the probability for ____ of the RFLPs and reducing ____ events

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1. Historically, this common X-linked disease was a problem, since carrier detection was unsatisfactory and prenatal diagnosis impossible. In the 1980s several closely linked DNA probes spanning the gene locus became available; thus increasing the probability for ____ of the RFLPs and reducing ____ events