In humans, the massive germline expansions at the DM1, DM2, FRAXA, SCA8, SCA10 and FRDA loci might involve recombination within the tract, probably by intra-chromosomal strand annealing (between sister chromatids) as a result of DNA synthesis-dependent strand annealing.

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1. In humans, the massive germline expansions at the DM1, DM2, FRAXA, SCA8, SCA10 and FRDA loci might involve recombination within the tract, probably by intra-chromosomal strand annealing (between sister chromatids) as a result of DNA synthesis-dependent strand annealing.