____ - large amounts of ____ excreted in the urine. This accumulation is due to abnormal cystathionase, a pyridoxal phosphate requiring enzyme. The enzyme has an altered binding site for pyridoxal and can function if supplied with large amounts of coenzyme.

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1. ____ - large amounts of ____ excreted in the urine. This accumulation is due to abnormal cystathionase, a pyridoxal phosphate requiring enzyme. The enzyme has an altered binding site for pyridoxal and can function if supplied with large amounts of coenzyme.