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These patients have a deletion of approximately the same region of chromosome 15 described above(The 15q11-q13 region contains three paternally expressed genes.), but on the maternally derived homolog. In this case, the information contained on the normal paternally derived chromosome 15 is inactivated due to DNA methylation.

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1. These patients have a deletion of approximately the same region of chromosome 15 described above(The 15q11-q13 region contains three paternally expressed genes.), but on the maternally derived homolog. In this case, the information contained on the normal paternally derived chromosome 15 is inactivated due to DNA methylation.





 
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