When the gene codes for a structural protein, all of which is necessary for normality, or when it is part of a multimeric protein, the related disease is classified as____; eg collagen where defects lead to ____

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1. When the gene codes for a structural protein, all of which is necessary for normality, or when it is part of a multimeric protein, the related disease is classified as____; eg collagen where defects lead to ____