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Give An Example Of How Important It Is To Have The Correct Ratio Of Th1 To Th2 Cells In An Immune Response?

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1. Give An Example Of How Important It Is To Have The Correct Ratio Of Th1 To Th2 Cells In An Immune Response?

Mycobacterium Leprae Is A Bacteria That Likes To Grow Intracellularly Inside Macrophages. It Is An Intracellular Bacteria So The Most Effective Immune Response Would Be A Intracellular Response Via Th1 T-cells. But, A Extracellular Response Could Result In An (Th2) Response Which Would Not Focus On The Bacteira Inside The Macrophages So The Infections Can Stay.
When A Microbe Invades The Body, Macrophages Take-up The Microbe Via Phagocytosis. This Is An Example Of Non-specific Immunity. It Must Then Travel To The Lymphnode To Be Presented Until A Immune Repsonse Can Be Started. If We Already Have Been Exposed To An Antigen, When Macrophages Phagocytosize An Antigen (If Its Primed) And Present It To A Cd4+ Th1 Memory Cell, It Causes The T-cell To Secrete Ifn-Î³ Which Upregulates The Macrophage And Causes A More Efficient Killing Of The Microbe. Inflammation Occurs Via Cyto/Chemokines Which Causes An Inflammation Response. If Not Resolved, A Granuloma Forms.
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Give An Example Of How Important It Is To Have The Correct Ratio Of Th1 To Th2 Cells In An Immune Response?

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