Wood painted his most famous work after a visit to Eldon, Iowa, when he saw a Carpenter Gothic-style house with a distinctive Gothic window in its gable. Upon returning to his studio, he used his sister Nan and his dentist, Dr. Byron McKeeby, as the models for the two figures. The pitchfork and the clothing were more typical of 19th-century farmers than contemporary ones. American Gothic is among the most familiar regionalist paintings, and it is said to be the most parodied of all paintings. It hangs at the Art Institute of Chicago, where it was submitted for a competition by Wood upon its completion in 1930 (Wood won a bronze medal and a $300 prize).