Slow, Writhing Movements, Mostly Noted In The Hands And Fingers = ?

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1. Slow, Writhing Movements, Mostly Noted In The Hands And Fingers = ?

Hypokineticclinical syndrome due to degeneration ofdopaminergicneurons fromsubstantia nigra pars compactato putamen; may be acceleratedaging or environmentaltoxin exposure (ex. Mptp -> mpt+ -> mitochondrial damage; ex. rotenone); onset age 40-70restingtremor,rigidity,bradykinesia, flexed posture; early: shuffling gait, micrographia, unilateral, masked facies; late: balance probs, orthostasis, dementia; dx: response to dopa, lewy bodies on histo l-dopa(1/3 improve, 1/3 same, 1/3 lose response) diff dx: essential tremor (only sx), drug-induced (neuroleptics, anti-htn, anti-emetics), other neurodegenerative dz (distinguish by dopa-response); compensation for striatal neuronal loss = decr. Da clearance; age-related loss of vmat2
At least 2 lesions in cnsseparated by space & time; polygenic inheritence; autoimmune vs. Cns myelin; damage by tnfÎ±; decr. T-suppressor fxn & incr. T-helper fxn; impaired transmission in cns; spinal cord lesions cause more sx than brain lesions, patchy, irregular(not bilateral symmetric) sclerotic plaques of periventricular areas (corpus callosum); oligodendrocyte degeneration (naked axons), astrocyte proliferation, perivenular inflammation; incr. intrathecal ig (in csf); sx:intranuclear ophthalmoplegia, optic neuritis, transverse myelitis; dx: hx of2 diff. Cns events(supported by exam) or hx of1 cns event w/ positive lumbar punctureprophylaxis:beta interferon= avonex, betaseron, copaxone -> reduce relapse & number of lesions; acute flare: iv steroid (solumedrol)most common cause of nontraumatic disability in young adults (18-60); do not treat w/ gamma inf -> worsens sx; symptomatic therapy to control spasticity, fatigue, urinary urgency; eae animal model; course = relapsing/remitting, rapidly progressive, benign; 50% need cane 15 yrs post-dx; dx by mri (t2 plaques), evoked potentials (visual most commonly abnl), lumbar puncture (oligoclonal antibody bands-> not devic's syndrome)
Vii (facial)
Athetosis

Slow, Writhing Movements, Mostly Noted In The Hands And Fingers = ?

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Slow, Writhing Movements, Mostly Noted In The Hands And Fingers = ?

❤ If you liked Fatskills, consider supporting us by checking out The Life Manuals You Never Got.

About | Explore | User Guide | Topics | Subjects | Doubt Solver | Career Aptitude Test | Answers | Free Tools | What Should We Know? Privacy | Terms |

Without work one finishes nothing. - Ralph Waldo Emerson© 2026 Fatskills.com

All trademarks, logos and brand names are the property of their respective owners. All company, product and service names used in this website are for identification purposes only. Use of these names, trademarks and brands does not imply endorsement.

About | Explore | User Guide | Topics | Subjects | Doubt Solver | Career Aptitude Test | Answers | Free Tools | What Should We Know?
Privacy | Terms |

Without work one finishes nothing. - Ralph Waldo Emerson
© 2026 Fatskills.com