Physician Assistant (PANCE) Practice Test
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The material on the PANCE and PANRE is organized by the NCCPA into two dimensions, as indicated in the content blueprint for the examination. - Organ systems and the diseases, disorders and medical assessments physician assistants encounter within those systems; and - The knowledge and skills physician assistants should exhibit when confronted with those diseases, disorders and assessments. Medical Content Categories % Allocation: Cardiovascular System 13% Dermatologic System 5% Endocrine System 7% Eyes, Ears, Nose, and Throat 7% Gastrointestinal System/Nutrition 9% Genitourinary... Show more
Physician Assistant (PANCE) Practice Test
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25 Questions

1. A 64-year-old male patient arrives at the clinic complaining of frequent upper abdominal pain, indigestion, weight loss, and oily, odorous stools. He says he has had these symptoms on and off for years. You diagnose him with chronic pancreatitis. Which of the following is most likely to be the cause of this condition?
2. Which of the following is the most common etiology of mesothelioma?
3. A 70-year-old female patient comes to the office complaining of abdominal pain. She states she has had heartburn for several weeks, but it is usually relieved with chewable antacid tablets. The pain appears to be worse when she is hungry or at night. When asked about the color of her stools, the patient said sometimes they are “dark.” She denies any frank blood in her stools. She has had no vomiting, but some nausea. She also complains of fatigue. Her medications are lisinopril for high blood pressure and Cosopt eye drops for glaucoma. She has osteoarthritis, for which she takes overthe- counter naproxen. When asked how much naproxen she takes, the patient states she takes “two or three every few hours when the pain is bad.” She doesn’t know the dosage she is taking. She states she has had more pain than usual in the last few weeks. What diagnosis do you suspect in this patient?
4. A 74-year-old female patient is seen at the clinic complaining of visual distortions, decreased brightness of colors, and blurriness in her left eye. Examination reveals retinal mottling, serous leaks, and hemorrhages. Which of the following diagnoses is most likely to be correct?
5. Which of the following women would be most at risk for developing uterine fibroids?
6. A 21-year-old male patient comes to the office complaining of a “funny-looking penis.” He appears very distressed. He says his penis is “bent down” when it is erect. The patient also says his “peehole” is located in the wrong place. He says he has to sit on the toilet to urinate to prevent urine from spraying in different directions. He says he is too embarrassed to have sexual intercourse. He has heard there is a type of surgery to correct his condition, but usually it is done on babies. After examining the patient, what do you tell him his condition is called?
7. A 28-year-old football player arrives in the emergency room with a forearm fracture. An X-ray reveals a fracture that runs diagonally across the bone. Which type of fracture has the patient endured?
8. Which of the following individuals would be most likely to be at risk of Thalassemia?
9. A 71-year-old male patient who is currently hospitalized after a hip replacement begins to show signs of sepsis. Which of the following symptoms would indicate a severe case of sepsis?
10. A 17-year-old male patient presents with a high fever, persistent headache, vomiting, and a stiff neck. He has also developed a petechial rash. You diagnose him with bacterial meningitis. Based on the patient’s symptoms, which of the following pathogens is most likely to be the cause of the patient’s condition?
11. You are treating a 78-year-old female patient for thyroiditis and you need to determine the specific form of the disease she is suffering from. Which of the following symptoms would indicate a diagnosis of Hashimoto’s thyroiditis?
12. A baker’s yeast allergy would be a contraindication for immunization with which of the following vaccines?
13. A 55-year-old female patient presents at the clinic with fever, cough, shortness of breath, and persistent hiccups. She also reports sharp chest pain that worsens when she coughs. You suspect she may be suffering from a pleural effusion and diagnostic testing reveals that the patient has an infection within the pleural space. Based on this information, from which type of pleural effusion is the patient suffering?
14. A 48-year-old female patient comes to the clinic complaining of a skin problem that is affecting her neck and face. Parts of the skin in those regions have become thickened and hard. She also shows slight signs of this condition around the distal region of her elbows. Further testing does not reveal any internal abnormalities. Which of the following diagnoses is most likely to be correct?
15. A 40-year-old male is suffering from an anorectal abscess causing anal swelling, erythema, and difficulty with defecation. Which of the following treatments would be most appropriate in this case?
16. A 30-year-old male patient who smokes is suffering from abdominal cramping, bloody diarrhea, and a slight fever. Examination reveals areas of bowel inflammation, particularly around the terminal ileum and right colon. Based on this information, which of the following diagnoses is most likely to be correct?
17. A pregnant 26-year-old patient in her 16th week presents at the clinic with vaginal bleeding and severe cramping. Upon examination, you find that no membranes have been ruptured, but her cervix is dilated. Which form of spontaneous abortion is she most likely experiencing?
18. A 17-year-old high school student comes to the office with what he says is a spider bite on top of his foot, which he has had for five days. There is a red, swollen, painful abscess on the top of his right foot. It is about 2 cm in diameter. The patient said he thinks he got the spider bite from walking barefoot in the school locker room after a wrestling match. He said the pustule will not go away, and it seems to be getting bigger and redder every day. You lance the abscess and biopsy it. What do you suspect is the cause of the boy’s condition?
19. A 19-year-old woman comes to the clinic complaining of localized, dull pain along the 2nd distal metatarsal area of the right foot. She states the pain happened spontaneously during running and was not related to any type of specific injury or trauma. The upper portion of the foot is slightly edematous, and when the 2nd metatarsal area is palpated, the patient complains of pain. She has difficulty lifting her toes on the affected foot. The patient is limping slightly. She states she has run track for 4 years, and is on the women’s track team in college. Recently the patient has stepped up her training to prepare for a major track event. An X-ray of her foot shows no obvious fracture. What is her most likely diagnosis?
20. A 58-year-old male patient arrives in the emergency room with chest pain and an apparent arrhythmia. His examination reveals ventricular tachycardia with symptomatic ventricular premature beats. He has not yet shown any signs of ventricular fibrillation and you want to prevent any such occurrence. Which of the following treatments would be most appropriate for the patient’s current condition?
21. A 47-year-old female patient arrives at the clinic complaining of severe left hip pain. The joint is warm, swollen, tender, and has limited range of movement. You diagnose her with septic arthritis. Diagnostic testing reveals that Staphylococcus aureus is the infecting pathogen. Based on this information, which of the following clinical interventions would be most necessary?
22. A 16-year-old female softball pitcher comes to the clinic complaining of pain and tenderness on the inside of her right elbow. She is a right-handed pitcher and reports increased pain that radiates down her forearm when she attempts to throw a ball. She has not fallen or suffered any direct trauma to the site recently. Based on this information, which of the following diagnoses is most likely to be correct?
23. A 16-year-old girl is brought to the clinic by her mother. She complains of throat pain and difficulty swallowing. She has low-grade fever and swollen and tender lymph nodes in the neck. You suspect streptococcal laryngitis. Which of the following diagnostic tests can be used to accurately confirm this diagnosis in as little time as possible?
24. A 57-year-old female patient arrives at the clinic complaining of vertigo-related symptoms such as dizziness, hearing loss, nausea, vomiting, and tinnitus. After her examination, she is determined to be suffering from Meniere’s disease. Based on this information, what form of vertigo is she experiencing?
25. A 65-year-old male patient arrives at the clinic complaining of gastrointestinal discomfort. Which of the following symptoms would be most likely to indicate that the patient is suffering from ulcerative colitis?

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