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The extracellular matrix (ECM) provides structural support to cells and tissues. It also generates cell signals that affect cell proliferation, differentiation, migration, and adhesion. ECM-cell interactions are mediated by cell surface receptors, either directly or indirectly with cooperative molecules. The ECM is also constantly remodeling, which influences cell-signaling pathways.
ECM-cell interactions play a crucial role in: Embryonic development Differentiation Tissue remodeling Diseases like fibrosis and cancer Dysregulated signaling between the ECM and cells can lead to different diseases.
Topics include: Cells Interaction - Integrins, Cells Interaction, Immunoglobulin Superfamily, Adherens Junctions, Tight Junctions, Gap Junctions, & Cell Walls.
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