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38 year old man collapses while running a marathon and is brought to the emergency department. His wife states that he is not in shape but still decided to run. Arterial blood gas on room air shows PaO2 of 100 mmHg, PaCO2 of 42 mm Hg and pH of 7.30. Further evaluation reveals metabolic acidosis with high anion gap. Increased activity of what biochemical pathway is basis for clinical findings? Why?

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The General Principles section of the USMLE covers these topics:
Biochemistry
Genetics
Microbiology
Pathology
Pharmacology


1. 38 year old man collapses while running a marathon and is brought to the emergency department. His wife states that he is not in shape but still decided to run. Arterial blood gas on room air shows PaO2 of 100 mmHg, PaCO2 of 42 mm Hg and pH of 7.30. Further evaluation reveals metabolic acidosis with high anion gap. Increased activity of what biochemical pathway is basis for clinical findings? Why?





 
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