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A 62 year old man with hx of osteoarthritis comes to doctor because of progressive pain in his knees despite treatment with aspirin. He states that the usual dose of the drug is no longer effective for treating his knee pain and that he has increased the dose and frequency of aspirin without consultin ghis physician. 1. WHat is the most likely eariliest sign or symptom of salicyclate intoxication this patient would experience? 2. What metabolic derangment can potentially occur?

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The General Principles section of the USMLE covers these topics:
Biochemistry
Genetics
Microbiology
Pathology
Pharmacology


1. A 62 year old man with hx of osteoarthritis comes to doctor because of progressive pain in his knees despite treatment with aspirin. He states that the usual dose of the drug is no longer effective for treating his knee pain and that he has increased the dose and frequency of aspirin without consultin ghis physician. 1. WHat is the most likely eariliest sign or symptom of salicyclate intoxication this patient would experience? 2. What metabolic derangment can potentially occur?





 
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