A 35 year old women comes to the ED due to 1 month hx of swelling of face, abdomen, lower limbs and 9 KG weight gain. Also has fever and night sweats over same period of time. Renal function is normal and urinalysis shows 4+ protein and no blood. 24 hr urine coleciton reveals 10 grams of proteinuria. Renal biopsy shows normal glomeruli on light microscopy and effacement of podocyte foot processes on electron microscopy. 1. What condition does this lady currently have? 2. What are the most common underlying conditions that cause this condition? 3. What neoplasm is a well known secondary cause of Minimal change disease in adults? 4. What findings suggest minimal change disease?

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Use the mnemonic, A WET BED: A) maintenance of ACID-base balance; W) maintenance of WATER balance; E) balance of ELECTROLYTES; T) removal of TOXINS; B) control of BLOOD pressure; E) production of ERYTHROPOIETIN; and D) metabolism of vitamin D.


1. A 35 year old women comes to the ED due to 1 month hx of swelling of face, abdomen, lower limbs and 9 KG weight gain. Also has fever and night sweats over same period of time. Renal function is normal and urinalysis shows 4+ protein and no blood. 24 hr urine coleciton reveals 10 grams of proteinuria. Renal biopsy shows normal glomeruli on light microscopy and effacement of podocyte foot processes on electron microscopy. 1. What condition does this lady currently have? 2. What are the most common underlying conditions that cause this condition? 3. What neoplasm is a well known secondary cause of Minimal change disease in adults? 4. What findings suggest minimal change disease?