16 year old comes to office due to amenorrhea. She has never had any menstrual bleeding. She is healthy, not sexually active. Immunizations up to date. Mother and sister had menarche at 13. Vitals and BMI are normal. Physical exam shows normal female external genitalia, a short vagina and Tanner stage 5 for breast and pubic hair. Labs show normal estrogen, FSH, LH, testosterone, TSH, prolacting. Genetics shows 46 XX karyotype. After pelvic sonography she is told she will never be able to get pregnant but she has possibility to have a genetic child with help of assisted reproductive technoligies. 1. Which embryological structure has most likely failed to develop properly in this patient? 2. What is this condition called? 3. What structures are often missing? 4. What is the status of the ovaries in these individuals?

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The development of the reproductive system begins with the formation of undifferentiated gonads and the paired mesonephric and paramesonephric ducts.


1. 16 year old comes to office due to amenorrhea. She has never had any menstrual bleeding. She is healthy, not sexually active. Immunizations up to date. Mother and sister had menarche at 13. Vitals and BMI are normal. Physical exam shows normal female external genitalia, a short vagina and Tanner stage 5 for breast and pubic hair. Labs show normal estrogen, FSH, LH, testosterone, TSH, prolacting. Genetics shows 46 XX karyotype. After pelvic sonography she is told she will never be able to get pregnant but she has possibility to have a genetic child with help of assisted reproductive technoligies. 1. Which embryological structure has most likely failed to develop properly in this patient? 2. What is this condition called? 3. What structures are often missing? 4. What is the status of the ovaries in these individuals?