A 55 year old women comes to office for foul smelling vaginal discharge. She has not seen doctor in 20 years. Pelvic speculum exam reveals an ulcerated friable cervical lesion. She subsequently undergoes a colposcopy with cervical biopsy which reveals poorly differentiated squamous cells. 1. What is the likely cause of this presentation? 2. This cause is also associated with what else? 3. Why are high risk HPV strains prone to oncogenesis? 4. What are the most common high risk HPV strains?

The development of the reproductive system begins with the formation of undifferentiated gonads and the paired mesonephric and paramesonephric ducts.