A 3 day old newborn develops a localized, crusted infection near the umbilical stump. 24 hours later, tender, reddened patches appear near the crusted area, progressing to painful and generalized skin erythema. By the next day, large, flaccid blisters appear that rupture easily. Large sheets of skin appear to have peeled off. 1. What is your diagnosis and why? 2. What causes it?

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Connective tissue is the most abundant type of tissue in the body. It serves to connect and support other tissues and also has regulatory and immunologic functions. Connective tissue consists of cells, mainly fibroblasts, and an extracellular matrix (ECM).


1. A 3 day old newborn develops a localized, crusted infection near the umbilical stump. 24 hours later, tender, reddened patches appear near the crusted area, progressing to painful and generalized skin erythema. By the next day, large, flaccid blisters appear that rupture easily. Large sheets of skin appear to have peeled off. 1. What is your diagnosis and why? 2. What causes it?