Presynaptic modulation occurs at axo-somatic synapses.

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Synaptic transmission is the process by which one neuron communicates with another. Information is passed down the axon of the neuron as an electrical impulse known as action potential. Once the action potential reaches the end of the axon it needs to be transferred to another neuron or tissue.
 

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Presynaptic modulation occurs at axo-somatic synapses.