As blood flows through systemic capillaries, carbonic acid dissociates into a bicarbonate ion and a hydrogen ion within the erythrocyte; the bicarbonate is moved out by the chloride shift while the hydrogen ion binds with hemoglobin.

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As blood flows through systemic capillaries, carbonic acid dissociates into a bicarbonate ion and a hydrogen ion within the erythrocyte; the bicarbonate is moved out by the chloride shift while the hydrogen ion binds with hemoglobin.