Tandem repeats may contribute to the morphological variation in a population. There is a correlation between the activity of some transcription factors and certain traits, for example, head shape and number of digits of the paw. The activity of Runx-2 transcription factor is influenced by tandem repeats within its open reading frame. These tandem repeats result in poly-Q and poly-A amino acid repeats in the Runx-2 protein. What characteristics of the repeats correlate with transcription factor activity?

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