In normal physiology the heart consumes fatty acids as it main source of energy. A failing heart has an _____________________________________________, and it is therefore unable to metabolize fatty acids for energy. The myocytes then begin using glucose for energy. _______________ increases and there is a decrease in mitochondrial activity. This lack of energy coupled with the high catecholamine levels causes an altered fatty acid oxidation and decreased effective ATP use and production.

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1. In normal physiology the heart consumes fatty acids as it main source of energy. A failing heart has an _____________________________________________, and it is therefore unable to metabolize fatty acids for energy. The myocytes then begin using glucose for energy. _______________ increases and there is a decrease in mitochondrial activity. This lack of energy coupled with the high catecholamine levels causes an altered fatty acid oxidation and decreased effective ATP use and production.