The atherosclerotic changes in the lower extremities lead to decreased perfusion which tends to be gradual. The decreased perfusion to the lower extremities causes pain with ambulation in the legs called intermittent claudication. This happens because during activity, the oxygen demand of the muscles in the legs cannot be met and they develop ischemia and pain. The pain will go away when they rest. This should sound to you very much like stable angina. This same type of principle happens when the individual has atherosclerosis which has affected the mesenteric vasculature, which perfuses the gut. This is called mesenteric ischemia and pain occurs after the person eats.

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1. The atherosclerotic changes in the lower extremities lead to decreased perfusion which tends to be gradual. The decreased perfusion to the lower extremities causes pain with ambulation in the legs called intermittent claudication. This happens because during activity, the oxygen demand of the muscles in the legs cannot be met and they develop ischemia and pain. The pain will go away when they rest. This should sound to you very much like stable angina. This same type of principle happens when the individual has atherosclerosis which has affected the mesenteric vasculature, which perfuses the gut. This is called mesenteric ischemia and pain occurs after the person eats.