The pathogenesis begins with a genetic predisposition or other factors which increase the risk. These factors lead to the development of obesity, insulin resistance, chronic inflammation, and dysfunction of the SNS, RAAS and natriuretic hormones.

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1. The pathogenesis begins with a genetic predisposition or other factors which increase the risk. These factors lead to the development of obesity, insulin resistance, chronic inflammation, and dysfunction of the SNS, RAAS and natriuretic hormones.