These changes include changes in the cross-linking of collagen, an increase in the amount of collagen, arterial calcification, changes in the nature of elastin, the presence of inflammatory molecules, and changes in endothelial cell function.

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1. These changes include changes in the cross-linking of collagen, an increase in the amount of collagen, arterial calcification, changes in the nature of elastin, the presence of inflammatory molecules, and changes in endothelial cell function.