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They inhibit the influx of calcium into the myocardium. This decreases intracellular calcium concentration which in turn decreases myocardial tension and contractility. They have negative inotropic effects. As such these medications should be avoided in persons with systolic heart failure.

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1. They inhibit the influx of calcium into the myocardium. This decreases intracellular calcium concentration which in turn decreases myocardial tension and contractility. They have negative inotropic effects. As such these medications should be avoided in persons with systolic heart failure.





 
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