The graph below shows the effectiveness of an enzyme at various temperatures ranging from 0 degrees Celsius to 60 degrees Celsius. What is the best explanation for the behavior of this enzyme at temperatures higher than approximately 40 degrees Celsius?

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The graph below shows the effectiveness of an enzyme at various temperatures ranging from 0 degrees Celsius to 60 degrees Celsius. What is the best explanation for the behavior of this enzyme at temperatures higher than approximately 40 degrees Celsius?