Paco has come to depend on heroin to be to function normally. A few weeks ago, he attempted to cut himself off, but he experienced severe diarrhea. Paco's case illustrates which of the following concepts?

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1. Paco has come to depend on heroin to be to function normally. A few weeks ago, he attempted to cut himself off, but he experienced severe diarrhea. Paco's case illustrates which of the following concepts?