to say that something happens or is true even though there is something that might prevent it from happeningDespite a thorough investigation, no trace of Dr Southwell has been found.Despite all our efforts to save the school, the authorities decided to close it.

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1. to say that something happens or is true even though there is something that might prevent it from happening
Despite a thorough investigation, no trace of Dr Southwell has been found.
Despite all our efforts to save the school, the authorities decided to close it.