Retrovirus - mediated transgenics (infect mouse embryo with retrovirus and implant) - pronuclear microinjection (introduce transgenic DNA during zygote development - inject into sperm or egg) - embryonic stem cell method (embryonic stem cells mixed w

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1. Retrovirus - mediated transgenics (infect mouse embryo with retrovirus and implant) - pronuclear microinjection (introduce transgenic DNA during zygote development - inject into sperm or egg) - embryonic stem cell method (embryonic stem cells mixed w