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You want to calculate the frequency of the allele causing sickle cell disease in your patients, and you know the genotypes of every individual. Assuming the population is not in H-W equilibrium due to population substructure, which method can be used to calculate allele frequency?

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1. You want to calculate the frequency of the allele causing sickle cell disease in your patients, and you know the genotypes of every individual. Assuming the population is not in H-W equilibrium due to population substructure, which method can be used to calculate allele frequency?





 
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