The HD locus has been mapped to position 4p16.3, where a gene IT15 coding for a predicted 348kDa protein (huntingtin) shows ____ in HD individuals (n>41).

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1. The HD locus has been mapped to position 4p16.3, where a gene IT15 coding for a predicted 348kDa protein (huntingtin) shows ____ in HD individuals (n>41).