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Study the following statements on alkylating agents as antineoplastics: [P]: They get converted to aziridinium ions and bind to 7th position -N atom of guanine of DNA base pairs [Q]: Nitrogen mustards and sulphur mustards belong to this class of drugs [R]: They inhibit dihydrofolatereductase enzyme thereby inhibiting DNA synthesis [S]: They chelate electropositive atoms present in the DNA thereby inhibiting DNA uncoiling Choose the correct combination of statements.

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Study the following statements on alkylating agents as antineoplastics: [P]: They get converted to aziridinium ions and bind to 7th position -N atom of guanine of DNA base pairs [Q]: Nitrogen mustards and sulphur mustards belong to this class of drugs [R]: They inhibit dihydrofolatereductase enzyme thereby inhibiting DNA synthesis [S]: They chelate electropositive atoms present in the DNA thereby inhibiting DNA uncoiling Choose the correct combination of statements.






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