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A single dose four-way cross over fasting, comparative bioavailability study was performed in 24 healthy, adult male subjects. Plasma drug concentration was obtained for each subject and following result was obtained: Product Dose (mg) Cmax (μg/ml) Tmax (h) AUC 0 → ∞ (μghr/ml) I. injection 100 1714 Oral emulsion 200 21.3 1.2 3143 Capsule 200 17 2.1 2822 Reference tablet 200 16.5 1.9 2715 The relative bioavailability of the drug from the capsule compared to the reference tablet is

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A single dose four-way cross over fasting, comparative bioavailability study was performed in 24 healthy, adult male subjects. Plasma drug concentration was obtained for each subject and following result was obtained: Product Dose (mg) Cmax (μg/ml) Tmax (h) AUC 0 → ∞ (μghr/ml) I. injection 100 1714 Oral emulsion 200 21.3 1.2 3143 Capsule 200 17 2.1 2822 Reference tablet 200 16.5 1.9 2715 The relative bioavailability of the drug from the capsule compared to the reference tablet is






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