Any event that changes the sequence of nucleotides on a molecule of DNA, which in turn changes the code for assembling a particular structural or metabolic protein; the alteration can change the shape of the protein, which can adversely affect its function.

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1. Any event that changes the sequence of nucleotides on a molecule of DNA, which in turn changes the code for assembling a particular structural or metabolic protein; the alteration can change the shape of the protein, which can adversely affect its function.