What is the BEST approach to manage regulatory and legal compliance in a global organization operating in multiple governmental jurisdictions with differing requirements?

ISACA CISM Exam syllabus in brief:

Information Security Governance    
A. Enterprise Governance
B. Information Security Strategy

Information Security Risk Management    
A. Information Security Risk Assessment
B. Information Security Risk Response

Information Security Program    
A. Information Security Program Development
B. Information Security Program Management

Incident Management    
A. Incident Management Readiness
B. Incident Management Operations