What is the interplay between brain sensing of osmolality, renal dilution or concentration of urine (output) and brain regulation of thirst (input) with â†‘ ECF osmolality?

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1. What is the interplay between brain sensing of osmolality, renal dilution or concentration of urine (output) and brain regulation of thirst (input) with â†‘ ECF osmolality?

Analogue of folic acid â†’ tightly binds to dihydrofolate reductase â†’ inhibits the enzyme (tetrahydrofolate) â†’ â†“ levels of tetrahydrofolate which is used to convert dUMP â†’ dTMP (thymidylate synthase) Methotrexate-induced direct inhibition of dihydrofolate reductase activity could lead to an indirect inhibition of the reation catalyzed by thymidylate synthase â†’ â†“ DNA synthesis At â†‘ concentrations methotrexate also inhibits de novo synthesis of purines
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â†‘ ECF osmolality (profound sweating, dehydration) â†’ action potential from osmoreceptor to release of anti-diuretic hormone (vasopressin) from pituitary â†’ production of urine which is low in volume and high in osmolality â†’ dilution of ECF by removal of solutes. In addition, thirst is stimulated by osmoreceptors to restore volume
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What is the interplay between brain sensing of osmolality, renal dilution or concentration of urine (output) and brain regulation of thirst (input) with â†‘ ECF osmolality?

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What is the interplay between brain sensing of osmolality, renal dilution or concentration of urine (output) and brain regulation of thirst (input) with â†‘ ECF osmolality?

❤ If you liked Fatskills, consider supporting us by checking out The Life Manuals You Never Got.

About | Explore | User Guide | Topics | Subjects | Doubt Solver | Career Aptitude Test | Answers | Free Tools | What Should We Know? Privacy | Terms |

Without work one finishes nothing. - Ralph Waldo Emerson© 2026 Fatskills.com

All trademarks, logos and brand names are the property of their respective owners. All company, product and service names used in this website are for identification purposes only. Use of these names, trademarks and brands does not imply endorsement.

About | Explore | User Guide | Topics | Subjects | Doubt Solver | Career Aptitude Test | Answers | Free Tools | What Should We Know?
Privacy | Terms |

Without work one finishes nothing. - Ralph Waldo Emerson
© 2026 Fatskills.com