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Achondroplasia is a disorder of bone whereby there is a mutation in the fibroblast growth factor receptor 3 (FGFR3) gene leading to impaired cartilage proliferation in the growth plate. Why is it that affected children have a normal sized head and vertebral column whilst arms and legs are shortened?

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Achondroplasia is a disorder of bone whereby there is a mutation in the fibroblast growth factor receptor 3 (FGFR3) gene leading to impaired cartilage proliferation in the growth plate. Why is it that affected children have a normal sized head and vertebral column whilst arms and legs are shortened?





 
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