Any enzyme that breaks a phosphodiester bond. degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization - duration - and amplitude of cyclic nucleotide signaling within subcellular domains.

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1. Any enzyme that breaks a phosphodiester bond. degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization - duration - and amplitude of cyclic nucleotide signaling within subcellular domains.