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Pharmacology: Anticoagulants
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Pharmacology: Anticoagulants
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23 Questions

1. Blood level of which clotting factor declines most rapidly after the initation of warfarin therapy
2. Severe cases of bleeding due to fibrinolytic agents are treated with
3. The most definite beneficial results are obtained in the use of anticoagulants for the following purpose
4. Anticoagulants are indicated in
5. Route of heparin administration is
6. Which of the following can be used to antagonize the action of heparin in case of overdose?
7. A patient on oral anticoagulant therapy is commenced on sulfamethoxazoletrimethoprim, double-strength twice daily. One may expect to see the INR I. Increase II. Decrease III. Remain unchanged
8. The anticoagulant effects of heparin can be promptly arrested by administration of
9. If a patient has an INR greater than 20 and active bleeding that is clinically significant (i.e., hematuria), the pharmacist should I. Hold the drug therapy II. Administer vitamin K III. Administer fresh frozen plasma
10. A patient to be commenced on oral anticoagulant therapy for DVT would be treated with: I. Oral anticoagulant therapy with warfarin for a goal international normalized ratio (INR) of 2–3 II. Oral anticoagulant therapy with warfarin for a goal INR of 2.5–3.5 III. Oral anticoagulant therapy with aspirin for a goal INR of 2–3
11. Low doses of heparin prolong
12. Initiation of unfractionated heparin therapy for the patient in question 1 would best be achieved with
13. The most important complication of streptokinase therapy is
14. Low molecular weight heparins differ from conventional heparin in that
15. Which preparation of Vitamin K should not be injected in the new born?
16. Low concentrations of heparin selectively interfere with the following coagulation patheay(s)
17. Which fibrioolytic drug(s) is/are antigenic
18. Which of the following tests are used to monitor antithrombotic therapy? I. International normalized ratio (INR) II. Activated partial thromboplastin time (APTT) III. Heparin assay
19. Unfractionated heparin binds to antithrombin III and inactivates clotting factor(s).
20. Thrombolytic therapy instituted within 3-6 hours of onset of acute myocardial infarction affords the following benefit(s)
21. The preferred route of administration of streptokinase in acute myocardial infarction is
22. The following drug reduces the effect of oral anticoagulants
23. Aspirin prolongs bleeding time by inhibiting the synthesis of

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